The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. The risk assessment was based mainly upon data from the open scientific Documentations and Methods. Keywords Skin absorption — Penetration enhancer — Epidermal water loss — Diethylene glycol monoethyl ether: Identifiers Diethylene glycol monoethyl ether [MAK Value Documentation, 2007]. Research paperEvaluation of the transepidermal permeation of Diethylene Glycol Monoethyl Ether (cas 111-90-0) and skin water loss; Add time:08/25/2019 Source:sciencedirect.com. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Protective gloves. It is mainly used as a solvent for paints and varnishes in the chemical industry, household detergents, brewing chemicals and textile processing. Eyes: Redness. diethylene glycol monoethyl ether was done by a member state (France). skin contact can be the major route of exposure. BACKGROUND A risk assessment on diethylene glycol monoethyl ether (DEGEE) with the chemical name 2-(2-ethoxyethoxy)ethanol and the INCI-name Ethoxydiglycol was done by a Member State (France). Opinion on diethylene glycol monoethyl ether (DEGEE) _____ 5 1. Ethylene glycol ethyl ether acetate. Molbase Encyclopedia provides diethylene glycol monoethyl ether (111-90-0) basic information, physical and chemical properties, safety information, toxicity, customs data, synthetic routes, maps, MSDS, generation methods and uses, and its upstream and downstream products, find diethylene glycol monoethyl ether introduction, on the Molbase Encyclopedia! DIETHYLENE GLYCOL MONOETHYL ETHER: ICSC: 0039: 2-(2-Ethoxyethoxy) ethanol 3, 6-Dioxa-1-octanol DEGEE: April 2004 Remove contaminated clothes. Diethylene glycol butyl ether (2-(2-Butoxyethoxy)ethanol) is an organic compound, one of several glycol ether solvents. Previous NIOSH studies demonstrated the embryo- and fetotoxicity and teratogenicity of ethylene glycol monoethyl ether (EGEE) applied to the shaved skin of pregnant rats. CAS Registry Number. It is particularly gaining importance in antimicrobial soaps, antiperspirants, nail polish removers, fragrances, hair dyes, and in products for treating acne, marks, and scars owing to its super solubilizing and efficacy boosting properties. They react with oxoacids and carboxylic acids to form esters plus water. extract the skin lipids or dimethyl sulfoxide (DMSO) that induces a garlic-like taste in the mouth after contact with the skin. DIETHYLENE GLYCOL MONOETHYL ETHER: ICSC: 0039: 2-(2-Ethoxyethoxy) ethanol 3, 6-Dioxa-1-octanol DEGEE: April 2004 2007. Cancer . Google has not performed a legal analysis and makes no representation as to the accuracy … 111-15-9. The risk assessment led the member state to put some restrictions on the use this substance. Skin: Dry skin. Synonym: 2-(2-Ethoxyethoxy)ethanol, CARBITOL ™, Diethylene glycol ethyl ether, Ethyldiglycol Linear Formula: C 2 H 5 OCH 2 CH 2 OCH 2 CH 2 OH Molecular Weight: 134.17 Diethylene glycol (DEG) is an organic compound with the formula (HOCH 2 CH 2) 2 O. Ethylene glycol monoethyl ether acetate [UN1172] [Flammable liquid] UN1172. Diethylene glycol monoethyl ether is used in the formulation of various cosmeceutical products as it has skin treatment properties. Listade är 21 internationella och pålitliga leverantörer för Diethylene glycol monoethyl ether. Ethoxyethanol, 2-, acetate. diethylene glycol monoethyl ether,physical properties,suppliers,CAS,MSDS,structure,Molecular Formula, Molecular Weight ,Solubility,boiling point, melting point Registrerade leverantörer av Diethylene glycol monoethyl ether över hela världen. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. Any troubles, come to us! * Used as a solvent and carrier in skin care products * Also known as Diethylene Glycol Monoethyl Ether Functions: According to RealSelf.com, Ethoxydiglycol is a clear, practically colorless, liquids used in cosmetics and personal care products.It is a solvent used to thin out products and decrease viscosity. Also, like other organic solvents, glycol ethers can dissolve your skin's natural protective oils, causing dryness, redness, flaking, cracking, and dermatitis (skin rash). If released to soil, triethylene glycol monoethyl ether is expected to have very high mobility based upon an estimated Koc of 10. Rinse skin with plenty of water or shower. Diethylene glycol monoethyl ether agent detailed information in Haz-Map database. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Ethylene glycol monoethyl ether acetate. The effect of diethylene glycol monoethyl ether (DGME; Transcutol) on the permeation of ivermectin, a broad-spectrum antiparasitic agent, through bovine skin was evaluated byin vitro permeation experiments followed by serial sectioning of the skin to assess the amount of ivermectin retained in the skin. The ether being relatively unreactive. EC Number 203-919-7. Beilstein/REAXYS Number 1736441 . It is miscible in water, alcohol, ether, acetone, and ethylene glycol. It is a colorless liquid with a low odour and high boiling point. In the present study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol monobutyl ether (EGBE), and diethylene glyc … EWG’s Skin Deep rates thousands of personal care product ingredients, ... ETHANOL, DIETHYLENE GLYCOL MONOETHYL ETHER, ETHANOL, 2(2ETHOXYETHOXY), ETHANOL, 2-(2-ETHOXYETHOXY)-, and ETHOXYDIGLYCOL. In the current study, diethylene glycol monoethyl ether-mediated microemulsions were combined with microneedles for enhanced transdermal aconitine delivery. We can give you the most professional suggestions to meet your products' requirements. Registry Numbers. Diethylene glycol ethyl ether acetate. Molecular Weight 134.17 . DEG is a widely used solvent. Structure, properties, spectra, suppliers and links for: 2-(2-Ethoxyethoxy)ethanol, 111-90-0, diethylene glycol monoethyl ether. EGEEA. The oil-in-water microemulsion increasedaconitine solubility and enhanced transdermal drug delivery and assistance with metal microneedles enhanced permeation of the aconitine-loaded microemulsion. Diethylene Glycol Monoethyl Ether Add to My Records Monograph ID: M4404. Publication date: 1 February 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 162 Author(s): Rosa Pireddu, Chiara Sinico, Guido Ennas, Michele Schlich, Donatella Valenti, Sergio Murgia, Francesca Marongiu, Anna Maria Fadda, Francesco Lai The poor ability of many drugs to cross skin layers is the main limiting factor for the exploitation of the transdermal route for drug delivery. Di(ethylene glycol) ethyl ether ≥99% Synonym: 2-(2-Ethoxyethoxy) ethanol, CARBITOL ™, Diethylene glycol ethyl ether, Diethylene glycol monoethyl ether, Ethyldiglycol CAS Number 111-90-0. Dessa leverantörer hör till 3 olika typer av företag som 'Producer' och '' Vapor-phase triethylene glycol monoethyl ether will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 8.5 hours. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Title: Diethylene Glycol Monoethyl Ether Molecular Formula: C 6 H 14 O 3. Results demonstrated that the presence of diethylene glycol monoethyl ether influences the Poloxamer 188 ability to stabilize the nanocrystals during the milling process, leading to larger particles as compared to penetration enhancer-free nanosuspensions. Linear Formula C 2 H 5 OCH 2 CH 2 OCH 2 CH 2 OH . Ethanol, 2-ethoxy-, acetate. Wear safety spectacles. First published: 14 August 2014 Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. RESULTS: Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. These two opposite fluxes and the alteration of the bulk constitution of the skin and of the donor compartment throughout the experiment, are important factors to be considered for the permeation studies with this solvent. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Diethylene Glycol Monoethyl Ether Manufacturers, Factory, Suppliers From China, We have more than 20 years experience in this industry, and our sales are well trained. Up to half of the applied solvent crosses the skin's … De kommer från 5 länder runt om i världen. diethylene glycol monoethyl ether compositions glycol monoethyl Prior art date 1996-04-10 Legal status (The legal status is an assumption and is not a legal conclusion. The rate of Transcutol® (TC)-water interchange, was studied using whole and stripped hairless rat skin in a modified vertical Franz diffusion cell. 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